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. 1974 Nov;6(5):606-12.
doi: 10.1128/AAC.6.5.606.

Effect of leucomycins and analogues on binding [14C ]erythromycin to Escherichia coli ribosomes

S Pestka, A Nakagawa, S Omura

Effect of leucomycins and analogues on binding [14C ]erythromycin to Escherichia coli ribosomes

S Pestka et al. Antimicrob Agents Chemother. 1974 Nov.

Abstract

We examined the effect of leucomycins, leucomycin derivatives, and other 16-membered macrolides (tylosin, niddamycin, spiramycin I, and spiramycin III) on [(14)C]erythromycin binding to ribosomes. Results of these studies enabled determination of the association and dissociation constants for the binding of each of these compounds to Escherichia coli ribosomes. In addition, the binding of the leucomycins and the leucomycin derivatives to ribosomes in general correlated with their antimicrobial activity.

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References

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