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. 1974 Nov;6(5):647-50.
doi: 10.1128/AAC.6.5.647.

Synthesis of vaccinia virus polypeptides in the presence of hydroxyurea

E Katz, E Margalith, B Winer

Synthesis of vaccinia virus polypeptides in the presence of hydroxyurea

E Katz et al. Antimicrob Agents Chemother. 1974 Nov.

Abstract

Hydroxyurea (5 x 10(-3) M) inhibits the development of vaccinia virus in HeLa cells early after infection and prevents the synthesis of viral deoxyribonucleic acid. In the presence of hydroxyurea, late viral polypeptides are not formed, as observed by electrophoresis on polyacrylamide gels.

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