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Comment
. 2005 Apr 19;102(16):5645-6.
doi: 10.1073/pnas.0501718102. Epub 2005 Apr 12.

Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation

Barbara L Hempstead  1
Affiliations
Comment

Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation

Barbara L Hempstead. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Schematic representation of neurotrophin activation of Trk and p75 receptors in cultured Schwann cells. (A) BDNF binds to the p75 receptor. (B) p75 activation leads to recruitment of a Src kinase, phosphorylation of Vav2, and activation of RhoA. (C) NT-3 binds to TrkC. (D) TrkC activation promotes phosphorylation of Dbs and activation of Cdc42. GEFs are shown in light green, and Rho family GTPases are shown in blue. dd, death domain; k, kinase.
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References

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