Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2005 Apr 19;102(16):5643-4.
doi: 10.1073/pnas.0501516102. Epub 2005 Apr 12.

Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse

Markus A Ruegg  1
Affiliations
Comment

Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse

Markus A Ruegg. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Development of the NMJ and the role of Syne-1. (A Left) Motor axons approach muscle fibers with myonuclei (gray) expressing high levels of clustered AChRs (green). (A Right) Mature NMJ with the presynaptic terminal containing aggregates of synaptic vesicles (white) and many mitochondria (orange). Nerve terminals are wrapped by Schwann cells. At the postsynaptic apparatus, AChRs (green) are concentrated at the crest of postsynaptic folds and myonuclei (black) and mitochondria accumulate. Extrasynaptic myonuclei (white) are transcriptionally distinct form subsynaptic ones. (B Upper) Structure of mouse Syne-1, the brain-specific alternative splice variant CPG2, and the dominant-negative form encoding the KASH domain used by Grady et al. (3). Red, calponin-type domains; blue, spectrin-like repeats; yellow, KASH domain. (B Lower) At the NMJ, agrin binds to the dystrophin-glycoprotein complex (DGC) via dystroglycan (red), activates MuSK, and aggregates AChRs. Utrophin binds to the DGC and the f-actin cytoskeleton. Syne-1 binds to f-actin and links it with the nuclear envelope (NE) via its KASH domain. Scheme is modified from ref. . (C) Mice overexpressing the KASH domain of Syne-1 lack subsynaptic myonuclei, and mitochondria are moving to the vicinity of the postsynaptic membrane. Gene expression in the perisynaptic (black) and extrasynaptic (white) myonuclei is as in wild-type mice.
See this image and copyright information in PMC

Comment on

References

    1. Morris, N. R. (2000) J. Cell Biol. 148, 1097–1101. - PMC - PubMed
    1. Rivera-Pomar, R. & Jackle, H. (1996) Trends Genet. 12, 478–483. - PubMed
    1. Grady, R. M., Starr, D. A., Ackermann, G. L., Sanes, J. R. & Han, M. (2005) Proc. Natl. Acad. Sci. USA 102, 4359–4364. - PMC - PubMed
    1. Fatt, P. & Katz, B. (1950) Nature 166, 597–598. - PubMed
    1. Sanes, J. R. & Lichtman, J. W. (2001) Nat. Rev. Neurosci. 2, 791–805. - PubMed

MeSH terms

LinkOut - more resources