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. 2005 Apr 21;3(8):1362-4.
doi: 10.1039/b500618j. Epub 2005 Mar 10.

A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

Kristian Rahbek Knudsen  1 , Karl Anker Jorgensen
Affiliations

A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

Kristian Rahbek Knudsen et al. Org Biomol Chem. .

Abstract

An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.

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