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. 1992 Mar;83(3):236-9.
doi: 10.1111/j.1349-7006.1992.tb00092.x.

HTLV-I uveitis: a distinct clinical entity caused by HTLV-I

M Mochizuki  1 , T Watanabe, K Yamaguchi, K Takatsuki, K Yoshimura, M Shirao, S Nakashima, S Mori, S Araki, N Miyata
Affiliations

HTLV-I uveitis: a distinct clinical entity caused by HTLV-I

M Mochizuki et al. Jpn J Cancer Res. 1992 Mar.

Abstract

Seroepidemiological, clinical and virological studies were carried out in an HTLV-I endemic area to find out if HTLV-I caused an intraocular inflammatory disorder, uveitis. The seroprevalence in patients with uveitis without defined etiologies (62/175, 35.4%) was significantly higher than that in patients with non-uveitic ocular diseases (42/261, 16.1%) or in patients with uveitis with defined etiologies (8/78, 10.3%). Moreover, the seroprevalence in young adults (20-49 years) with uveitis without defined etiologies was 30/67 (44.8%), whereas it was only 10/107 (9.3%) in the other two groups. The uveitis in HTLV-I carriers was characterized clinically by a moderate inflammation of the vitreous body accompanied by a mild iritis and retinal vasculitis. The proviral DNA of HTLV-I was detected by polymerase chain reaction from the inflammatory cells in the anterior chamber in 9 out of 9 seropositive patients with the uveitis, but not in any of the tested patients with other types of uveitis. These data, thus, indicate that HTLV-I causes a specific type of intraocular inflammation, uveitis.

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