HTLV-I uveitis: a distinct clinical entity caused by HTLV-I
- PMID: 1582883
- PMCID: PMC5918816
- DOI: 10.1111/j.1349-7006.1992.tb00092.x
HTLV-I uveitis: a distinct clinical entity caused by HTLV-I
Abstract
Seroepidemiological, clinical and virological studies were carried out in an HTLV-I endemic area to find out if HTLV-I caused an intraocular inflammatory disorder, uveitis. The seroprevalence in patients with uveitis without defined etiologies (62/175, 35.4%) was significantly higher than that in patients with non-uveitic ocular diseases (42/261, 16.1%) or in patients with uveitis with defined etiologies (8/78, 10.3%). Moreover, the seroprevalence in young adults (20-49 years) with uveitis without defined etiologies was 30/67 (44.8%), whereas it was only 10/107 (9.3%) in the other two groups. The uveitis in HTLV-I carriers was characterized clinically by a moderate inflammation of the vitreous body accompanied by a mild iritis and retinal vasculitis. The proviral DNA of HTLV-I was detected by polymerase chain reaction from the inflammatory cells in the anterior chamber in 9 out of 9 seropositive patients with the uveitis, but not in any of the tested patients with other types of uveitis. These data, thus, indicate that HTLV-I causes a specific type of intraocular inflammation, uveitis.
References
-
- ) Blattner , W. A. , “ Human Retro virology: HTLV ,” pp. 25 – 65 ( 1990. ). Raven Press; , New York .
-
- ) Tajima , K. , The T and B Cell Malignancy Study Group, Co‐authors. The 4th nation‐wide study of adult T cell leukemia/lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features . Int. J. Cancer , 45 , 237 – 243 ( 1990. ). - PubMed
-
- ) Yoshida , M. , Seiki , M. , Yamaguchi , K. and Takatsuki , K.Monoclonal integration of human T‐cell leukemia provirus in all primary tumors of adult T‐cell leukemia suggests causative role of human T‐cell leukemia virus in the disease . Proc. Natl. Acad. Sci. USA , 81 , 2534 – 2537 ( 1984. ). - PMC - PubMed
-
- ) Gessain , A. , Barin , F. , Vernant , J. C. , Gout , O. , Calender , A. and de The , G.Antibodies to the human T‐lymphotropic virus type‐I in patients with tropical spastic para‐paresis . Lancet , ii , 407 – 410 ( 1985. ). - PubMed
-
- ) Osame , M. , Usuku , K. , Izumo , S. , Ihichi , N. , Amitani , H. , Igata , A. , Matsumoto , M. and Tara , M.HTLV‐I associated myelopathy, a new clinical entity . Lancet , i , 1031 – 1032 ( 1986. ). - PubMed
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