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. 2005 Apr;11(4):590-6.
doi: 10.3201/eid1104.040833.

Childhood hemolytic uremic syndrome, United Kingdom and Ireland

Richard M Lynn  1 , Sarah J O'Brien, C Mark Taylor, Goutam K Adak, Henrik Chart, Tom Cheasty, John E Coia, Iain A Gillespie, Mary E Locking, William J Reilly, Henry R Smith, Aoife Waters, Geraldine A Willshaw
Affiliations

Childhood hemolytic uremic syndrome, United Kingdom and Ireland

Richard M Lynn et al. Emerg Infect Dis. 2005 Apr.

Abstract

We conducted prospective surveillance of childhood hemolytic uremic syndrome (HUS) from 1997 to 2001 to describe disease incidence and clinical, epidemiologic and microbiologic characteristics. We compared our findings, where possible, with those of a previous study conducted from 1985 to 1988. The average annual incidence of HUS for the United Kingdom and Ireland (0.71/100,000) was unchanged from 1985 to 1988. The overall early mortality had halved, but the reduction in mortality was almost entirely accounted for by improved outcome in patients with diarrhea-associated HUS. The principal infective cause of diarrhea-associated HUS was Shiga toxin-producing Escherichia coli O157 (STEC O157), although in the 1997-2001 survey STEC O157 phage type (PT) 21/28 had replaced STEC O157 PT2 as the predominant PT. The risk of developing diarrhea-associated HUS was significantly higher in children infected with STEC O157 PT 2 and PT 21/28 compared with other PTs. Hypertension as a complication of HUS was greatly reduced in patients with diarrhea-associated HUS.

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Figures

Figure
Figure
Laboratory-confirmed infection with Shiga toxin–producing Escherichia coli O157 in the United Kingdom, 1982–2001. Data sources: Public Health Laboratory Service and Scottish Center for Infection and Environmental Health.
See this image and copyright information in PMC

References

    1. Fitzpatrick M. Haemolytic uraemic syndrome and E. coli O157. BMJ. 1999;318:684–5. 10.1136/bmj.318.7185.684 - DOI - PMC - PubMed
    1. Banatvala N, Griffin PM, Greene KD, Barrett TJ, Bibb WF, Green JH, et al. The United States National Prospective Hemolytic Uremic Syndrome Study: microbiologic, serologic, clinical, and epidemiologic findings. J Infect Dis. 2001;183:1063–70. 10.1086/319269 - DOI - PubMed
    1. Milford DV, Taylor CM, Guttridge B, Hall SM, Rowe B, Kleanthous H. Haemolytic uraemic syndromes in the British Isles 1985–8: association with verocytotoxin producing Escherichia coli. Part 1: clinical and epidemiological aspects. Arch Dis Child. 1990;65:716–21. 10.1136/adc.65.7.716 - DOI - PMC - PubMed
    1. Kleanthous H, Smith HR, Scotland SM, Gross RJ, Rowe B, Taylor CM, et al. Haemolytic uraemic syndromes in the British Isles, 1985–8: association with verocytotoxin producing Escherichia coli. Part 2: microbiological aspects. Arch Dis Child. 1990;65:722–7. 10.1136/adc.65.7.722 - DOI - PMC - PubMed
    1. Gerber A, Karch H, Allerberger F, Verweyen HM, Zimmerhackl LB. Clinical course and the role of shiga toxin–producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997–2000, in Germany and Austria: a prospective study. J Infect Dis. 2002;186:493–500. 10.1086/341940 - DOI - PubMed

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