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. 1974 Sep;6(3):360-5.
doi: 10.1128/AAC.6.3.360.

Inhibition of herpes simplex virus replication by phosphonoacetic acid

L R Overby, E E Robishaw, J B Schleicher, A Rueter, N L Shipkowitz, J C Mao

Inhibition of herpes simplex virus replication by phosphonoacetic acid

L R Overby et al. Antimicrob Agents Chemother. 1974 Sep.

Abstract

Replication of herpes simplex virus in WI-38 cells was inhibited by phosphonoacetic acid, as measured by decreased virus cytopathogenic effect and incorporation of radiolabeled thymidine in virus-infected cells. The drug appeared to have no effect on adsorption, penetration, or release of the virus nor on the synthesis of ribonucleic acid or protein. It appeared to inhibit virus deoxyribonucleic acid synthesis.

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References

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