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. 1974 Sep;6(3):369-71.
doi: 10.1128/AAC.6.3.369.

Dihydrofolate reductase in Pediococcus cerevisiae strains susceptible and resistant to amethopterin

F Mandelbaum-Shavit, N Grossowicz

Dihydrofolate reductase in Pediococcus cerevisiae strains susceptible and resistant to amethopterin

F Mandelbaum-Shavit et al. Antimicrob Agents Chemother. 1974 Sep.

Abstract

A mutant strain of Pediococcus cerevisiae was obtained which had 1,000-fold greater resistance to amethopterin than the P. cerevisiae/PteGlu strain. The dihydrofolate reductase level of the mutant was about 60-fold higher than that of the parent. The mutant accumulated folate, though less efficiently than its parent.

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References

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