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. 2005 Apr;20(2):340-3.
doi: 10.3346/jkms.2005.20.2.340.

Analysis of loss of heterozygosity in Korean patients with keratoacanthoma

Tae-Won Ha  1 , Ki-Hwan Han, Dae-Gu Son, Sang-Pyo Kim, Dae-Kwang Kim
Affiliations

Analysis of loss of heterozygosity in Korean patients with keratoacanthoma

Tae-Won Ha et al. J Korean Med Sci. 2005 Apr.

Abstract

Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been reported. The purpose of this study was to investigate the significance of LOH in the pathogenesis of sporadic keratoacanthomas developed in 10 Korean patients. The presents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160, D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detected in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas.

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Figures

Fig. 1
Fig. 1
LOH at chromosome region 10q (D10S185) in patient No. 10. The arrow indicates the reduction of signal intensity in tumor (T) DNA as compared with corresponding normal (N) DNA.
See this image and copyright information in PMC

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