Review
[Na,K-ATPase and cardiac glycosides: new functions of the known protein]
[Article in
Russian]
- PMID: 15835539
Item in Clipboard
Review
[Na,K-ATPase and cardiac glycosides: new functions of the known protein]
[Article in
Russian]
Ross Fiziol Zh Im I M Sechenova.
2005 Feb.
Abstract
Review of hormonal function of endogenous cardiac steroids. Special attention is paid to recently discovered mechanism of signal transduction from Na,K-ATPase that is due to not a change of ionic gradients but to ouabain-induced alteration of enzyme conformation, that, in turn, results in interaction of the enzyme with intracellular proteins. The data concerning discovery and identification of endogenous cardiac steroids and different isoforms of Na,K-ATPase that have various sensitivity to cardiac steroid, are also considered.
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