Regulation of Akt/PKB Ser473 phosphorylation
- PMID: 15837416
- DOI: 10.1016/j.molcel.2005.03.020
Regulation of Akt/PKB Ser473 phosphorylation
Abstract
For years the Akt/PKB research field has been in turmoil, trying to understand how the activating phosphorylation of Akt/PKB at Ser473 is regulated. In the past month, papers in a recent issue of Molecular Cell (Gao et al., 2005) and in Science (Sarbassov et al., 2005) may have identified the phosphatase and kinase acting on this residue.
Comment on
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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.Mol Cell. 2005 Apr 1;18(1):13-24. doi: 10.1016/j.molcel.2005.03.008. Mol Cell. 2005. PMID: 15808505
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