Linkage disequilibrium: ancient history drives the new genetics
- PMID: 15838181
- DOI: 10.1159/000085226
Linkage disequilibrium: ancient history drives the new genetics
Abstract
This brief review provides a summary of the biological causes of genetic association between tightly linked markers--termed linkage disequilibrium--and unlinked markers--termed population structure. We also review the utility of linkage disequilibrium data in gene mapping in isolated populations, in the estimation of recombination rates and in studying the history of particular alleles, including the detection of natural selection. We discuss current understanding of the extent and patterns of linkage disequilibrium in the genome, and its promise for genetic association studies in complex disease. Finally, we highlight the importance of using appropriate statistical procedures, such as the false discovery rate, to maximize the chances of success in large scale association studies.
Similar articles
-
A multilocus model for constructing a linkage disequilibrium map in human populations.Stat Appl Genet Mol Biol. 2009;8:Article 18. doi: 10.2202/1544-6115.1419. Epub 2009 Feb 26. Stat Appl Genet Mol Biol. 2009. PMID: 19341352
-
On selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci.Genet Epidemiol. 2003 Jan;24(1):57-67. doi: 10.1002/gepi.10217. Genet Epidemiol. 2003. PMID: 12508256 Review.
-
Not all isolates are equal: linkage disequilibrium analysis on Xq13.3 reveals different patterns in Sardinian sub-populations.Hum Genet. 2002 Jul;111(1):9-15. doi: 10.1007/s00439-002-0753-z. Epub 2002 Jun 18. Hum Genet. 2002. PMID: 12136230
-
Evaluation of linkage disequilibrium measures between multi-allelic markers as predictors of linkage disequilibrium between markers and QTL.Genet Res. 2005 Aug;86(1):77-87. doi: 10.1017/S001667230500769X. Genet Res. 2005. PMID: 16181525
-
Using linked markers to infer the age of a mutation.Hum Mutat. 2001 Aug;18(2):87-100. doi: 10.1002/humu.1158. Hum Mutat. 2001. PMID: 11462233 Review.
Cited by
-
Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.Am J Hum Genet. 2005 Nov;77(5):754-67. doi: 10.1086/497345. Epub 2005 Sep 20. Am J Hum Genet. 2005. PMID: 16252236 Free PMC article.
-
Sequence features in regions of weak and strong linkage disequilibrium.Genome Res. 2005 Nov;15(11):1519-34. doi: 10.1101/gr.4421405. Genome Res. 2005. PMID: 16251462 Free PMC article.
-
Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages.Am J Hum Genet. 2015 Aug 6;97(2):228-37. doi: 10.1016/j.ajhg.2015.06.001. Epub 2015 Jul 9. Am J Hum Genet. 2015. PMID: 26166477 Free PMC article.
-
Insights into lysosomal cobalamin trafficking: lessons learned from cblF disease.J Mol Med (Berl). 2010 May;88(5):459-66. doi: 10.1007/s00109-010-0601-x. Epub 2010 Feb 20. J Mol Med (Berl). 2010. PMID: 20174775 Review.
-
Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5. doi: 10.1073/pnas.0610124104. Epub 2006 Dec 29. Proc Natl Acad Sci U S A. 2007. PMID: 17197413 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources