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Review
. 2005;59(2):118-24.
doi: 10.1159/000085226. Epub 2005 Apr 18.

Linkage disequilibrium: ancient history drives the new genetics

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Review

Linkage disequilibrium: ancient history drives the new genetics

Gonçalo R Abecasis et al. Hum Hered. 2005.

Abstract

This brief review provides a summary of the biological causes of genetic association between tightly linked markers--termed linkage disequilibrium--and unlinked markers--termed population structure. We also review the utility of linkage disequilibrium data in gene mapping in isolated populations, in the estimation of recombination rates and in studying the history of particular alleles, including the detection of natural selection. We discuss current understanding of the extent and patterns of linkage disequilibrium in the genome, and its promise for genetic association studies in complex disease. Finally, we highlight the importance of using appropriate statistical procedures, such as the false discovery rate, to maximize the chances of success in large scale association studies.

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