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Comment
. 2005 Apr 26;102(17):5903-4.
doi: 10.1073/pnas.0502045102. Epub 2005 Apr 19.

Symmetrical recognition of cellular DNA target sequences during retroviral integration

Duane P Grandgenett  1
Affiliations
Comment

Symmetrical recognition of cellular DNA target sequences during retroviral integration

Duane P Grandgenett. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Cellular DNA target site selection by integrase before integration. The ends of the viral 10-kbp linear DNA (angled) are not connected in this drawing. The host DNA is represented by the horizontal DNA structure and does not take into account the chromatin structure of DNA in vivo. The potential insertion sites are indicated by two red dots on the host DNA. The 2-bp 3′ OH recessed viral DNA ends are adjacent to the host DNA, with the 2-bp viral DNA overhang shown as 5′. The four black dashed ovals (labeled IN) represent two dimers of IN (tetramer) bound to the viral and host DNA. The host nucleotides bound by IN at and outside of the insertion sites (sequence pattern) vary for each virus, and their approximate locations are bracketed. In this model, the two ends of the viral DNA bound with IN are partners for symmetrical recognition of the host target site.
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