Altered regional blood flow in the fetus: the origins of cardiovascular disease?
- PMID: 15841760
Altered regional blood flow in the fetus: the origins of cardiovascular disease?
Abstract
A fetal response to hypoxia and other adverse influences is to redistribute blood flow in order to "spare" the brain. This, however, is associated with reduced growth of the liver and kidneys.
Conclusion: The long-term consequences of fetal redistribution of blood flow are unknown, but preliminary evidence suggests that there is an increased risk of coronary heart disease and hypertension in later life.
Comment on
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Foetal growth of kidneys, liver and spleen in intrauterine growth restriction: "programming" causing "metabolic syndrome" in adult age.Acta Paediatr. 2004 Dec;93(12):1635-9. doi: 10.1080/08035250410023106. Acta Paediatr. 2004. PMID: 15841773
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