doi: 10.1021/ol050370y.
An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis
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- PMID: 15844904
- DOI: 10.1021/ol050370y
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An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis
Org Lett.
.
Abstract
[reaction: see text] A new, robust tert-butyldiarylsilyl (TBDAS) linker has been developed for solid-phase organic synthesis. This linker is stable to both protic and Lewis acidic reaction conditions, overcoming a significant limitation of previously reported silyl linkers. Solid-phase acetal deprotection, olefination, asymmetric allylation, and silyl protecting group deblocking reactions have been demonstrated with TBDAS-linked substrates.
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