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. 2005 Apr;68(4):572-3.
doi: 10.1021/np049650x.

Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata

Yoshitaka Ikeda  1 , Hikaru Nonaka, Tamotsu Furumai, Yasuhiro Igarashi
Affiliations

Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata

Yoshitaka Ikeda et al. J Nat Prod. 2005 Apr.

Abstract

A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.

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