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Review
. 2005 May;73(5):2573-85.
doi: 10.1128/IAI.73.5.2573-2585.2005.

Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation

Junkal Garmendia  1 , Gad Frankel, Valérie F Crepin
Affiliations
Review

Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation

Junkal Garmendia et al. Infect Immun. 2005 May.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Genetic organization of the EPEC/EHEC LEE and EHEC prophages CP-933U, CP-933K, and CP-933P. The image was generated using coliBase (http://colibase.bham.ac.uk/) (21).
FIG. 2.
FIG. 2.
Schematic representation of the EPEC/EHEC type III secretion apparatus. The basal body of the TTSS is composed of the secretin EscC, the inner membrane proteins EscR, EscS, EscT, EscU, and EscV, and the EscJ lipoprotein, which connects the inner and outer membrane ring structures. EscF constitutes the needle structure, whereas EspA subunits polymerize to form the EspA filament. EspB and EspD form the translocation pore in the host cell plasma membrane, connecting the bacteria with the eukaryotic cell via EspA filaments. The cytoplasmic ATPase EscN provides the energy to the system by hydrolyzing ATP molecules into ADP. SepD and SepL have been represented as cytoplasmic components of the TTSS.
FIG. 3.
FIG. 3.
EPEC and EHEC translocate LEE-encoded and other effector proteins into the host cell cytosol. These effectors trigger cytoskeleton rearrangements (Tir, EspH, EspF, and EspG), disruption of the epithelial barrier (EspF and Map), cytotoxicity (EspF and Cif), and host cell responses that ultimately generate watery diarrhea. Different from EPEC Tir, EHEC Tir is not tyrosine phosphorylated and does not interact with Nck in order to trigger actin polymerization at the site of bacterial adhesion; instead, EHEC translocates an effector protein, TccP/EspFu, which has an Nck-like activity and is essential to promote the reorganization of the actin cytoskeleton underneath adherent EHEC bacteria. ER, endoplasmic reticulum.
See this image and copyright information in PMC

References

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