Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Aug 1;106(3):1130-2.
doi: 10.1182/blood-2004-12-4988. Epub 2005 Apr 21.

BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients

Veronique Erard  1 , Hyung Woo Kim, Lawrence Corey, Ajit Limaye, Meei-Li Huang, David Myerson, Chris Davis, Michael Boeckh
Affiliations

BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients

Veronique Erard et al. Blood. .

Abstract

We performed a case-control study to determine the association of BK plasma viremia with hemorrhagic cystitis (HC) in hematopoietic cell transplant (HCT) recipients. Thirty cases of HC (14 of which occurred after platelet engraftment with documented BK viruria [BK-HC]) were compared with matched controls. Weekly plasma samples were tested for BK virus DNA by polymerase chain reaction (PCR). BK viremia detected before or during the disease was independently associated with HC (adjusted odds ratio = 30, P < .001); BK viremia was even important before clinical symptoms of HC occurred (odds ratio = 11, P < .001). Cases of HC and BK-HC had a significantly higher peak of BK plasma viral load than controls. BK virus was detected by in situ hybridization in bladder biopsies of 2 cases with severe HC and long-lasting BK viremia. BK virus seems to play a role in the development of HC and quantitative detection of BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Proportion of patients and controls with BK viremia. (A) The proportion of patients among controls and cases in each subset of HC who developed BK viremia at any level before or during HC. Post-eng indicates postengraftment. (B) The proportion of patients among controls and cases in each subset of HC who developed BK viremia above 104 copies/mL. The sensitivity and the specificity of PCR-based BK viremia at any level either before or at time of HC was 86% and 75%, respectively, for clinical HC, and 92% and 72%, respectively, for postengraftment HC with documented BK viruria. The sensitivity and the specificity of BK viremia before HC was 66% and 85%, respectively, for clinical HC, and 92% and 88%, respectively, for postengraftment HC with documented BK viruria. Plasma BK viral load that measured above 104 copies/mL before or during HC had a sensitivity and specificity of 63% and 95%, respectively, for diagnosing HC; and 57% and 95%, respectively, for diagnosing postengraftment HC with documented BK viruria.
See this image and copyright information in PMC

References

    1. Apperley JF, Rice SJ, Bishop JA, et al. Late-onset hemorrhagic cystitis associated with urinary excretion of polyomaviruses after bone marrow transplantation. Transplantation. 1987;43: 108-112. - PubMed
    1. Arthur RR, Shah KV, Baust SJ, Santos GW, Saral R. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med. 1986;315: 230-234. - PubMed
    1. Leung AY, Suen CK, Lie AK, Liang RH, Yuen KY, Kwong YL. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood. 2001;98: 1971-1978. - PubMed
    1. Bedi A, Miller CB, Hanson JL, et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol. 1995;13: 1103-1109. - PubMed
    1. Lion T, Baumgartinger R, Watzinger F, et al. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood. 2003;102: 1114-1120. - PubMed

Publication types

MeSH terms