High prevalence of circulating CD4+CD28- T-cells in patients with small abdominal aortic aneurysms
- PMID: 15845908
- DOI: 10.1161/01.ATV.0000167520.41436.c0
High prevalence of circulating CD4+CD28- T-cells in patients with small abdominal aortic aneurysms
Abstract
Objective: To assess the possible role of proinflammatory CD28- T cells in abdominal aortic aneurysms (AAAs). Animal studies and human tissue studies suggest a role for interferon (IFN)-gamma-producing T cells in the development and progression of AAAs.
Methods and results: Fluorescence-activated cells sorter analysis of peripheral blood samples and measurement of AAA size using sonography were performed in 101 AAA patients and 38 healthy controls. Peripheral percentages of CD28- T cells of the CD3+CD4+ and the CD3+CD8+ were enriched in AAA patients with 7.8+/-8.8% and 41.9+/-15.7% compared with healthy controls with 2.2+/-6.1% and 24.9+/-15.5%, respectively (P=0.002 and P<0.001, respectively). Both CD4+CD28- and CD8+CD28- T cells produced large amounts of IFN-[gamma] and perforin. Patients with small AAAs (<4 cm) showed higher peripheral levels of CD4+CD28- T cells than those with larger AAAs (P=0.025). Immunohistological examinations revealed 39.1+/-17.2% CD4+CD28- and 44.0+/-13.8% CD8+CD28- in AAA tissue specimens with inflammatory infiltratestes.
Conclusions: IFN-gamma- and perforin-producing CD28- T cells are present in the periphery and the vessel wall of a majority of AAAs. This observation in humans favors the concept of a T cell-mediated pathophysiology of AAAs, especially during the early development of AAAs.
Comment in
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CD8+ T-cell subpopulations in human abdominal aortic aneurysm lesion.Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):e19; author reply e19-20. doi: 10.1161/01.ATV.0000199249.15199.80. Arterioscler Thromb Vasc Biol. 2006. PMID: 16424356 No abstract available.
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