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Comparative Study
. 1992 May 15;89(10):4663-7.
doi: 10.1073/pnas.89.10.4663.

Dodeca satellite: a conserved G+C-rich satellite from the centromeric heterochromatin of Drosophila melanogaster

J P Abad  1 , M Carmena, S Baars, R D Saunders, D M Glover, P Ludeña, C Sentis, C Tyler-Smith, A Villasante
Affiliations
Comparative Study

Dodeca satellite: a conserved G+C-rich satellite from the centromeric heterochromatin of Drosophila melanogaster

J P Abad et al. Proc Natl Acad Sci U S A. .

Abstract

To identify sequences from the centromeric region, we have constructed a Drosophila melanogaster yeast artificial chromosome (YAC) library and screened it with purified DNA from the minichromosome Dp(1;f)1187 derived from the X chromosome. We describe the structure of one clone isolated in this way. This YAC is structurally unstable and contains tandemly repeated G+C-rich 11-mer and 12-mer units, which we call dodeca satellite. Most of this satellite is located near the centromere of an autosome. Cross-hybridizing sequences are found in the genomes of organisms as distant as Arabidopsis thaliana and Homo sapiens.

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