Long-term results of pediatric renal transplantation at one center in Turkey

Abstract

Kidney transplantation is more frequently indicated in children than in adults because growth retardation is an additional problem associated with chronic kidney disease in the pediatric age group. This study retrospectively analyzed the data from 75 kidney transplantations performed on 73 children (38 male and 35 female) at a center in Turkey from late 1975 through 2003. The aim of the study was to investigate the case characteristics and the long-term outcomes in this patient group. Patient ages ranged from 8 to 16 years (mean, 14.9 +/- 2.2 years). Sixty (82.1%) children were on hemodialysis, and 12 (16.4%) on peritoneal dialysis prior to transplantation. Pre-emptive transplantation was performed for one (1.4%) patient. Fifty-nine transplantations used organs from live donors (78.7%) and 16 cadaver transplants (21.3%). The mean cold ischemia time for the cadaveric transplantations was 38.6 hours (range, 23-56 hours). All recipients were placed on a low-dose immunosuppressive regimen. One graft was lost due to hyperacute rejection. Twenty-one patients (28.8%) experienced a total of 24 acute rejection episodes. The follow-up period ranged from 1 to 190 months (mean, 44.1 +/- 31.8 months). Concerning postoperative complications, four patients (5.5%) developed a lymphocele; there were two cases each (2.7% each) of distal ureteral stricture, perirenal hematoma, or renovascular stenosis; and one patient (1.4%) developed a urine leakage. Two patients (2.7%) developed Kaposi's sarcoma at 17 and 3 months after transplantation. Six recipients died (mortality 8%), four of whom had a functioning graft. Two patients (2.7%) underwent retransplantation at 4 and 2 years after the initial operation. The 1-, 3-, and 5-year graft survival rates for living-related transplantations were 92%, 81%, and 70%, and the corresponding patient survival rates were 98%, 93%, and 92%, respectively. The 1-, 3-, and 5-year graft survival rates for cadaveric transplantations were 90%, 78%, and 68%, and patient survival rates 98%, 91%, and 90%, respectively. These results indicate that kidney transplantation is successful in pediatric end-stage renal disease patients particularly from living-related donors.