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. 2005 May 16;13(10):3413-21.
doi: 10.1016/j.bmc.2005.03.009.

Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids

Julieta Coro  1 , Rolando Pérez, Hortensia Rodríguez, Margarita Suárez, Celeste Vega, Miriam Rolón, David Montero, Juan José Nogal, Alicia Gómez-Barrio
Affiliations

Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids

Julieta Coro et al. Bioorg Med Chem. .

Abstract

Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A.

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