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Meta-Analysis
. 2005 May 7;11(17):2656-61.
doi: 10.3748/wjg.v11.i17.2656.

Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: a systematic review and meta-analysis

Xiang Ding  1 , Lian-Yue Yang, Geng-Wen Huang, Jian-Qing Yang, He-Li Liu, Wei Wang, Ji-Xiang Peng, Jie-Quan Yang, Yi-Ming Tao, Zhi-Gang Chang, Xiu-Shou Ling
Affiliations
Meta-Analysis

Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: a systematic review and meta-analysis

Xiang Ding et al. World J Gastroenterol. .

Abstract

Aim: To identify the role of alpha-fetoprotein (AFP) mRNA expression in peripheral blood one week after surgery as a predictor for recurrence of hepatocellular carcinoma (HCC).

Methods: Published studies fulfilling the selection criteria were identified by searching several databases online. After a methodology assessment using a quality scale designed by European Lung Cancer Working Party, data in each research were aggregated by means of meta-analysis.

Results: Altogether 368 cases were included in the 9 selected studies, which fulfilled the selection criteria. The quality scores ranged from 35% to 84% with a median score of 55%. The 'design' subscore had the lowest median value (38%). By aggregating the data, a high chi2 value (77.576) was presented. The fail-safe number was 136 and 64 for P = 0.05 and 0.01, respectively.

Conclusion: AFP mRNA expression in peripheral blood 1 wk after surgery correlated with the recurrence of HCC and was a good predictor for tumor recurrence.

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