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Review
. 2005 Apr;48(2):347-51.
doi: 10.1016/j.brainresrev.2004.12.023.

Preservation of DNA integrity and neuronal degeneration

Simona Francisconi  1 , Mara Codenotti, Giulia Ferrari-Toninelli, Daniela Uberti, Maurizio Memo
Affiliations
Review

Preservation of DNA integrity and neuronal degeneration

Simona Francisconi et al. Brain Res Brain Res Rev. 2005 Apr.

Abstract

The mismatch repair system (MMR) is an important member of the DNA checkpoint, that includes a number of protein deputed to control genomic stability through cell cycle arrest, DNA repair, and apoptosis. Here we summarize some recent data from our and other groups underlining the contribution to neurodegeneration of MSH2, perhaps the most relevant component of the MMR system. These data suggest that this protein participates not only in the cancer prevention machinery for the body but also in neurodegenerative processes.

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