Review
doi: 10.1016/j.cell.2005.04.003.
Two birds with one stone--dealing with nuclear transport and spindle assembly
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- PMID: 15851021
- DOI: 10.1016/j.cell.2005.04.003
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Review
Two birds with one stone--dealing with nuclear transport and spindle assembly
Cell.
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Abstract
Spindle assembly and nuclear transport both utilize the same simple device: Ran-GTP-sensitive interaction of importin beta and its cargo proteins. In this issue of Cell, report that one of these cargos required for spindle assembly turns out to be Rae1, previously known as an mRNA export protein. This study reveals the importance of RNAs in spindle structure.
Comment on
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A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.Cell. 2005 Apr 22;121(2):223-34. doi: 10.1016/j.cell.2005.02.016. Cell. 2005. PMID: 15851029
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