Comparative Study
doi: 10.1126/science.1585181.
DNA hydrolyzing autoantibodies
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- PMID: 1585181
- DOI: 10.1126/science.1585181
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Comparative Study
DNA hydrolyzing autoantibodies
Science.
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Abstract
A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.
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