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Comparative Study
. 1992 May 1;256(5057):665-7.
doi: 10.1126/science.1585181.

DNA hydrolyzing autoantibodies

A M Shuster  1 , G V Gololobov, O A Kvashuk, A E Bogomolova, I V Smirnov, A G Gabibov
Affiliations
Comparative Study

DNA hydrolyzing autoantibodies

A M Shuster et al. Science. .

Abstract

A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.

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