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. 2005 May 1;39(1):16-22.
doi: 10.1097/01.qai.0000155036.03004.a0.

T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection

Jutta K Neuenburg  1 , Tracey A Cho, Annelie Nilsson, Barry M Bredt, Samuel J Hebert, Robert M Grant, Richard W Price
Affiliations

T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection

Jutta K Neuenburg et al. J Acquir Immune Defic Syndr. .

Abstract

We characterized T cell phenotypes in 74 paired blood and cerebrospinal fluid (CSF) samples of HIV-infected and uninfected persons using four-color flow cytometry. CD4+ and CD8+ T cells subsets were further characterized by identifying activated/resting and memory/naive subsets in CSF and blood using the markers CD38/HLA-DR and CD45RA/CD62L, respectively. With and without HIV-infection, the proportion of CD4+ T cells and memory T cells among T cells in CSF was higher compared to blood. In HIV-infection, activated CD4+ and CD8+ T cells in CSF were more abundant than in uninfected controls. As expected, combination antiretroviral therapy (ART) reduced T cell activation in CSF and blood.

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