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Case Reports
. 1992 May;85(5):545-7.
doi: 10.1097/00007611-199205000-00017.

Sirenomelia accompanying exposure of the embryo to cocaine

S Sarpong  1 , V Headings
Affiliations
Case Reports

Sirenomelia accompanying exposure of the embryo to cocaine

S Sarpong et al. South Med J. 1992 May.

Abstract

We have reported two cases of sirenomelia sequence associated with a history of cocaine exposure during a major part or the entire extent of the first trimester of pregnancy. The two infants were delivered during a 2 1/2-year interval in a newborn population in which prenatal cocaine exposure rose to an estimated 25%. The incidence of sirenomelia in this population was 18-fold higher than previously reported. The potential relationship between sirenomelia and cocaine exposure during the first month of pregnancy warrants further investigation.

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