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. 2005 May;57(5):738-41.
doi: 10.1002/ana.20457.

Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

Pierre Castelnau  1 , Laura Cif, Enza Maria Valente, Nathalie Vayssiere, Simone Hemm, Amandine Gannau, Annalisa Digiorgio, Philippe Coubes
Affiliations

Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

Pierre Castelnau et al. Ann Neurol. 2005 May.

Abstract

Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and functional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.

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