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. 2005 May;49(5):2095-7.
doi: 10.1128/AAC.49.5.2095-2097.2005.

Spread of a Klebsiella pneumoniae strain producing a plasmid-mediated ACC-1 AmpC beta-lactamase in a teaching hospital admitting disabled patients

Salomon Ohana  1 , Veronique Leflon, Esthel Ronco, Martin Rottman, Didier Guillemot, Sylvie Lortat-Jacob, Pierre Denys, Georges Loubert, Marie-Helène Nicolas-Chanoine, Jean-Louis Gaillard, Christine Lawrence
Affiliations

Spread of a Klebsiella pneumoniae strain producing a plasmid-mediated ACC-1 AmpC beta-lactamase in a teaching hospital admitting disabled patients

Salomon Ohana et al. Antimicrob Agents Chemother. 2005 May.

Abstract

We describe a large outbreak involving a Klebsiella pneumoniae strain producing a plasmid-encoded ACC-1 type AmpC beta-lactamase in a hospital caring for patients with motor impairment. The epidemic strain was isolated from 57 patients in six wards between September 1999 and May 2003 and caused clinical infections in 19 patients.

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Figures

FIG. 1.
FIG. 1.
β-Lactam susceptibility pattern of the epidemic ACC-1-producing K. pneumoniae strain (disk diffusion method on Mueller-Hinton agar). Note the following: (i) the resistance to cefotaxime, ceftazidime, aztreonam, and cefotetan; (ii) the susceptibility to cefepime and cefoxitin; (iii) the lack of synergy between ceftazidime, cefotaxime, aztreonam, cefepime, and clavulanate; (iv) the inhibition zone of cefoxitin was greater than that of cefotetan (diameters of 19 to 25 mm versus 16 to 20 mm, respectively) and antagonism between cefoxitin and clavulanate. Abbreviations: TCC, ticarcillin-clavulanate; CAZ, ceftazidime; FOX, cefoxitin; FEP, cefepime; ATM, aztreonam; CTX, cefotaxime; and CTT, cefotetan.
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