Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii

Abstract

Objective: Environmental factors such as infectious agents may contribute to the psychopathology and aetiology of schizophrenia. Toxoplasma gondii (TG) is a candidate infectious agent as it is known to replicate within the human central nervous system and to alter behaviour in experimental animals.

Method: The relationship between antibodies to TG and psychopathological symptoms was examined in 34 first-episode patients with schizophrenia.

Results: Results of regression analyses revealed that symptoms on admission, predictors of outcome, age and family history of psychiatric disease influenced the levels of antibodies to TG.

Conclusions: These results indicate that TG infections may play a role in the clinical manifestation of psychopathology in a subgroup of patients with schizophrenia.