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Comparative Study
. 2005 May;61(6):736-40.
doi: 10.1016/s0016-5107(05)00321-4.

Effectiveness of glycerol as a submucosal injection for EMR

Toshio Uraoka  1 , Takahiro Fujii, Yutaka Saito, Tetsuya Sumiyoshi, Fabian Emura, Pradeep Bhandari, Takahisa Matsuda, Kuang-I Fu, Daizo Saito
Affiliations
Comparative Study

Effectiveness of glycerol as a submucosal injection for EMR

Toshio Uraoka et al. Gastrointest Endosc. 2005 May.

Abstract

Background: EMR traditionally is performed by using normal saline solution (NS) as the submucosal fluid cushion. It is thought, however, that NS does not maintain the proper mucosal elevation for EMR of large, flat lesions. We investigated the efficacy of glycerol as the submucosal injection solution.

Methods: A total of 110 colorectal laterally spreading tumors (LST) were treated by EMR with glycerol. For comparison, 113 LSTs treated by using NS were studied. The en bloc resection, complete resection, and associated complications rates were evaluated retrospectively.

Observations: The en bloc resection rate in the glycerol group was 63.6% (70/110) compared with 48.9% (55/113) in the NS group (p < 0.05). The complete resection rate in the glycerol group was 45.5% (50/110) compared with 24.6% (28/113) in the NS group (p < 0.01). The associated complications rate was similar in both groups.

Conclusions: It technically was easier and as safe to perform EMR of colorectal LSTs when using glycerol as the submucosal injection solution.

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