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. 2005 Aug;54(8):1062-6.
doi: 10.1136/gut.2004.063685. Epub 2005 Apr 27.

Increasing incidence of Barrett's oesophagus in the general population

E M van Soest  1 , J P Dieleman, P D Siersema, M C J M Sturkenboom, E J Kuipers
Affiliations

Increasing incidence of Barrett's oesophagus in the general population

E M van Soest et al. Gut. 2005 Aug.

Abstract

Background: Barrett's oesophagus (BO) predisposes to oesophageal adenocarcinoma. Epidemiological data suggest that the incidence of BO is rising but it is unclear whether this reflects a true rise in incidence of BO or an increase in detection secondary to more upper gastrointestinal endoscopies performed. This study aimed to examine the changes in BO incidence relative to the number of upper gastrointestinal endoscopies performed in the general population.

Methods: We conducted a cohort study using the Integrated Primary Care Information database. This general practice research database contains the complete and longitudinal electronic medical records of more than 500,000 persons.

Results: In total, 260 incident cases of BO were identified during the study period. The incidence of BO increased from 14.3/100,000 person years in 1997 (95% confidence interval (CI) 8.6-22.4) to 23.1/100,000 person years (95% CI 17.2-30.6) in 2002 (r2 = 0.87). The number of upper gastrointestinal endoscopies decreased from 7.2/1000 person years (95% CI 6.7-7.7) to 5.7/1000 person years (95% CI 5.4-6.1) over the same time period. This resulted in an overall increase in detected BO per 1000 endoscopies from 19.8 (95% CI 12.0-31.0) in 1997 to 40.5 (95% CI 30.0-53.5) in 2002 (r2 = 0.93). The incidence of adenocarcinoma increased from 1.7/100,000 person years (95% CI 0.3-5.4) in 1997 to 6.0/100,000 person years (95% CI 3.3-10.2) in 2002 (r2 = 0.87).

Conclusion: The incidence of diagnosed BO is increasing, independent of the number of upper gastrointestinal endoscopies that are being performed. This increase in BO incidence will likely result in a further increase in the incidence of oesophageal adenocarcinomas in the near future.

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Figures

Figure 1
Figure 1
Age related risk for a person to be diagnosed with Barrett’s oesophagus over the coming 10 years.
Figure 2
Figure 2
Incidence of Barrett’s oesophagus per 1000 upper gastrointestinal endoscopies over calendar time, with upper and lower confidence intervals (CI).
Figure 3
Figure 3
Age and sex specific incidence of Barrett’s oesophagus per 1000 upper gastrointestinal endoscopies over calendar time. Points represent three year moving ranges.
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References

    1. Pera M, Cameron AJ, Trastek VF, et al. Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology 1993;104:510–13. - PubMed
    1. Blot WJ, Devesa SS, Fraumeni JF Jr. Continuing climb in rates of esophageal adenocarcinoma: an update. JAMA 1993;270:1320. - PubMed
    1. Bytzer P, Christensen PB, Damkier P, et al. Adenocarcinoma of the esophagus and Barrett’s esophagus: a population-based study. Am J Gastroenterol 1999;94:86–91. - PubMed
    1. Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265:1287–9. - PubMed
    1. Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049–53. - PubMed