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. 2005 Apr 28;3(1):17.
doi: 10.1186/1479-5876-3-17.

Adoptive T cell therapy: Addressing challenges in cancer immunotherapy

Cassian Yee  1
Affiliations

Adoptive T cell therapy: Addressing challenges in cancer immunotherapy

Cassian Yee. J Transl Med. .

Abstract

Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the treatment of patients with cancer. In this review, the advantages and limitations of using antigen-specific T cells are discussed in counterpoint to vaccine strategies. Although vaccination strategies represent more readily available reagents, adoptive T cell therapy provides highly selected T cells of defined phenotype, specificity and function that may influence their biological behavior in vivo. Adoptive T cell therapy offers not only translational opportunities but also a means to address fundamental issues in the evolving field of cancer immunotherapy.

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