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. 2005 Sep;26(18):1846-51.
doi: 10.1093/eurheartj/ehi287. Epub 2005 Apr 28.

Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events

Tanja K Krempl  1 , Renke Maas, Karsten Sydow, Thomas Meinertz, Rainer H Böger, Jan Kähler
Affiliations

Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events

Tanja K Krempl et al. Eur Heart J. 2005 Sep.

Abstract

Aims: We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina.

Methods and results: Forty-five patients with stable angina, 36 patients with unstable angina, and 40 healthy controls were included in this study. Coronary artery disease (CAD) patients were prospectively followed for 1 year. ADMA levels were measured at baseline and after 6 weeks using a validated ELISA. Baseline ADMA concentration in controls was significantly lower than in patients with CAD (0.59+/-0.23 vs. 0.76+/-0.17 micromol/L; P<0.001). Patients with unstable angina had significantly higher baseline ADMA levels than patients with stable angina (0.82+/-0.18 vs. 0.73+/-0.15 micromol/L; P=0.01). There was a significant reduction of ADMA levels at 6 weeks after percutaneous coronary intervention (PCI) in patients with unstable angina who experienced no recurrent cardiovascular event (from 0.81+/-0.14 to 0.73+/-0.19 micromol/L; P<0.05). In contrast, patients with unstable angina who had an event showed no significant decrease in ADMA at 6 weeks. Actuarial survival analysis showed a significantly higher event rate in patients with persistently elevated ADMA plasma concentrations.

Conclusion: ADMA is significantly elevated in patients with unstable angina. A reduced ADMA level at 6 weeks after PCI may indicate a decreased risk of recurrent cardiovascular events.

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