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. 1992 Apr;51(4):437-9.
doi: 10.1136/ard.51.4.437.

Increased risk of cancer in patients with systemic lupus erythematosus

T Pettersson  1 , E Pukkala, L Teppo, C Friman
Affiliations

Increased risk of cancer in patients with systemic lupus erythematosus

T Pettersson et al. Ann Rheum Dis. 1992 Apr.

Abstract

To evaluate the risk of cancer in patients with systemic lupus erythematosus (SLE) a series of 205 consecutive patients (182 women and 23 men) were followed up for cancer through the files of the Finnish Cancer Registry. The follow up consisted of a total of 2340 person years. Fifteen cancers were diagnosed against 5.7 expected (relative risk (RR) 2.6, 95% confidence interval (CI) 1.5 to 4.4). Among the women there were four non-Hodgkin's lymphomas against 0.09 expected (RR 44, CI 11.9 to 111) and two soft tissue sarcomas against 0.04 expected (RR 49, CI 6.0 to 177). When evaluated by a case control study previous treatment with cytostatic drugs showed no influence on the occurrence of cancer in this series of patients with SLE.

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