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. 2005 Jun;29(6):625-32.
doi: 10.1016/j.leukres.2004.11.018. Epub 2005 Feb 17.

Therapy-related myelodysplastic syndrome in childhood: a retrospective study of 36 patients in Japan

M Tsurusawa  1 , A Manabe, Y Hayashi, Y Akiyama, H Kigasawa, H Inada, Y Noguchi, N Sawai, R Kobayashi, Y Nagatoshi, K Kawakami, S Kojima, T Nakahata; MDS committee of the Japanese Society of Pediatric Hematology
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Therapy-related myelodysplastic syndrome in childhood: a retrospective study of 36 patients in Japan

M Tsurusawa et al. Leuk Res. 2005 Jun.

Abstract

We report here a retrospective analysis of 36 children with therapy-related myelodysplastic syndrome (t-MDS) diagnosed between 1990 and 1999 in Japan. Their median age was 7.7 years and the median latency period for the development of t-MDS was 38.5 months. The primary tumors were hematologic in 15 of the cases and nonhematologic in 21. Chromosomal abnormalities were detected in 32/34(94%) patients: abnormalities of chromosomes 5and/or 7 in 41% and notably, 11q23 abnormalities in 31%. The prognosis of children with t-MDS was very poor as compared to children with primary MDS (5 year survival: 16% versus 54%, p<0.0001).

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