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Clinical Trial
. 2005 Sep;90(9):892-7.
doi: 10.1136/adc.2004.060673. Epub 2005 Apr 29.

Effects of probiotics on atopic dermatitis: a randomised controlled trial

S Weston  1 , A Halbert, P Richmond, S L Prescott
Affiliations
Clinical Trial

Effects of probiotics on atopic dermatitis: a randomised controlled trial

S Weston et al. Arch Dis Child. 2005 Sep.

Abstract

Background: The aim of the study was to investigate the effects of probiotics on moderate or severe atopic dermatitis (AD) in young children.

Methods: Fifty six children aged 6-18 months with moderate or severe AD were recruited into a randomised double blind placebo controlled trial in Perth, Western Australia; 53 children completed the study. The children were given a probiotic (1x10(9)Lactobacillus fermentum VRI-033 PCC; Probiomics) or an equivalent volume of placebo, twice daily for 8 weeks. A final assessment at 16 weeks was performed.

Results: The main outcome measures were severity and extent of AD at the end of the study, as measured by the Severity Scoring of Atopic Dermatitis (SCORAD) index. The reduction in the SCORAD index over time was significant in the probiotic group (p = 0.03) but not the placebo group. Significantly more children receiving probiotics (n = 24, 92%) had a SCORAD index that was better than baseline at week 16 compared with the placebo group (n = 17, 63%) (p = 0.01). At the completion of the study more children in the probiotic group had mild AD (n = 14, 54%) compared to the placebo group (n = 8, 30%).

Conclusion: Supplementation with probiotic L fermentum VRI-003 PCC is beneficial in improving the extent and severity of AD in young children with moderate or severe disease.

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Figures

Figure 1
Figure 1
Consort statement: progress of participants through the trial.
Figure 2
Figure 2
Change in extent and severity of AD during the study. (A) The differences in the SCORAD index from baseline (box plot) are shown for the probiotic L fermentum VRI-003 PCC group (shaded boxes) and the placebo group (white boxes) at each follow up visit. (B) Baseline and follow up (week 16) SCORAD index scores are shown for each participant in the placebo and probiotic groups. (C) The proportion of children in the mild, moderate, and severe categories of AD at baseline, end of supplementation (week 8), and at follow up are presented for the placebo and probiotic groups.
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References

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