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Clinical Trial
. 2005 May;162(5):1013-6.
doi: 10.1176/appi.ajp.162.5.1013.

The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R McGurk  1 , Cameron Carter, Robert Goldman, Michael F Green, Stephen R Marder, Haiyi Xie, Nina R Schooler, John M Kane
Affiliations
Clinical Trial

The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R McGurk et al. Am J Psychiatry. 2005 May.

Abstract

Objective: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia.

Method: Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial.

Results: Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance.

Conclusions: The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.

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