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Comment
. 2005 May;115(5):1139-42.
doi: 10.1172/JCI24930.

Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease

Shinji Tamura  1 , Iichiro Shimomura
Affiliations
Comment

Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease

Shinji Tamura et al. J Clin Invest. 2005 May.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a component of the metabolic syndrome, with a clinical spectrum ranging from simple fatty liver to steatohepatitis, cirrhosis, and hepatocellular carcinoma. The primary event of NAFLD is the accumulation of triacylglycerols (TAGs) in hepatocytes. In this issue of the JCI, Donnelly et al. report on their use of stable isotope methodology to show that fatty acids stored in adipose tissue and fatty acids newly made within the liver through de novo lipogenesis are the major sources of TAGs in the liver and are secreted as lipoproteins in NAFLD.

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Figures

Figure 1
Figure 1
A 6-month-old girl with typical clinical findings of Caffey disease, which appeared at age 7 weeks. The painful swelling of soft tissue around the legs (A) is matched by severe involvement of the tibia and fibula bilaterally (x-radiography, B). Femurs are strikingly unaffected.
See this image and copyright information in PMC

Comment on

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