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Case Reports
. 2006 Feb;22(2):189-92.
doi: 10.1007/s00381-005-1151-3. Epub 2005 Apr 30.

Successful treatment of multiple Pseudallescheria boydii brain abscesses and ventriculitis/ependymitis in a 2-year-old child after a near-drowning episode

Kay Mursch  1 , Svorad Trnovec, Heinrich Ratz, Detlef Hammer, Regine Horré, Albrecht Klinghammer, Sybren de Hoog, Julianne Behnke-Mursch
Affiliations
Case Reports

Successful treatment of multiple Pseudallescheria boydii brain abscesses and ventriculitis/ependymitis in a 2-year-old child after a near-drowning episode

Kay Mursch et al. Childs Nerv Syst. 2006 Feb.

Abstract

Rationale: We report on a cerebral infection by Pseudallescheria boydii in a 21-month-old boy after a near-drowning episode. MRI revealed multiple (> 60) intracerebral abscesses.

Methods: The surgical therapy included CSF drainage and microsurgical resection of one abscess for microbiological diagnosis. Antimycotic therapy included terbinafine and intraventricular caspofungin in addition to voriconazole.

Results: Systemic side effects of chemotherapy were not observed. After placement of a ventriculoperitoneal shunt, the boy was transferred to a rehabilitation clinic and improved neurologically. After 20 months, MRI documented a continuing remission of the disease.

Conclusion: Our case proves that an aggressive treatment should be undertaken and can be successful in CNS pseudallescheriasis.

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