Review
doi: 10.1016/j.bbrc.2005.03.183.
Death squads enlisted by the tumour suppressor p53
Affiliations
- PMID: 15865934
- DOI: 10.1016/j.bbrc.2005.03.183
Item in Clipboard
Review
Death squads enlisted by the tumour suppressor p53
Biochem Biophys Res Commun.
.
Abstract
p53 is a tumour suppressor that is found mutated or functionally inactivated in more than half of all human cancers. p53 function is activated by DNA damage, hypoxia, expression of certain oncogenes, and many cytotoxic stimuli. p53 is a transcription factor that regulates expression of target genes which promote apoptotic cell death, cell cycle arrest, cellular senescence, and some other processes. In this review we summarise current knowledge of p53 target genes implicated in apoptosis signalling.
Similar articles
-
Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.Oncogene. 2002 Apr 11;21(16):2534-44. doi: 10.1038/sj.onc.1205340. Oncogene. 2002. PMID: 11971188
-
Stress-induced p53 runs a transcription-independent death program.Biochem Biophys Res Commun. 2005 Jun 10;331(3):843-50. doi: 10.1016/j.bbrc.2005.03.187. Biochem Biophys Res Commun. 2005. PMID: 15865940 Review.
-
Paradox of Bcl-2 (and p53): why may apoptosis-regulating proteins be irrelevant to cell death?Bioessays. 2001 Oct;23(10):947-53. doi: 10.1002/bies.1135. Bioessays. 2001. PMID: 11598961 Review.
-
p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines.Head Neck. 2006 Jan;28(1):15-23. doi: 10.1002/hed.20319. Head Neck. 2006. PMID: 16302195
-
Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells.Oncol Rep. 2008 Feb;19(2):517-26. Oncol Rep. 2008. PMID: 18202802
Cited by
-
Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis.J Exp Clin Cancer Res. 2010 Dec 17;29(1):167. doi: 10.1186/1756-9966-29-167. J Exp Clin Cancer Res. 2010. PMID: 21167021 Free PMC article.
-
Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.Sci Rep. 2016 Feb 25;6:21968. doi: 10.1038/srep21968. Sci Rep. 2016. PMID: 26912277 Free PMC article.
-
How cell death shapes cancer.Cell Death Dis. 2015 Mar 5;6(3):e1675. doi: 10.1038/cddis.2015.20. Cell Death Dis. 2015. PMID: 25741600 Free PMC article. Review.
-
A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.Nat Commun. 2014 Nov 27;5:5567. doi: 10.1038/ncomms6567. Nat Commun. 2014. PMID: 25429397 Free PMC article.
-
Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability.Genome Med. 2012 Jun 28;4(6):55. doi: 10.1186/gm354. eCollection 2012. Genome Med. 2012. PMID: 22741526 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
