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Comment
. 2005 May;8(5):626-7.
doi: 10.1016/j.devcel.2005.04.008.

Wnt/beta-catenin--a canonical tale of cell-fate choice in the vertebrate skeleton

Elona Kolpakova  1 , Bjorn R Olsen
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Wnt/beta-catenin--a canonical tale of cell-fate choice in the vertebrate skeleton

Elona Kolpakova et al. Dev Cell. 2005 May.
Free article

Abstract

Three exciting papers in this issue of Developmental Cell provide new insights into the regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal development and postnatal growth. The studies demonstrate that Wnt/beta-catenin signaling represents both a mechanism in mesenchymal precursor cells for selecting between chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the production of an inhibitor of osteoclast formation.

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