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. 2005 Jun 1;191(11):1988-91.
doi: 10.1086/429964. Epub 2005 Apr 25.

Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis

Jacques Brouard  1 , Nicola Knauer, Pierre-Yves Boelle, Harriet Corvol, Alexandra Henrion-Caude, Cyril Flamant, François Bremont, Bertrand Delaisi, Jean-Francois Duhamel, Christophe Marguet, Michel Roussey, Marie-Claude Miesch, Katarina Chadelat, Michele Boule, Brigitte Fauroux, Felix Ratjen, Hartmut Grasemann, Annick Clement
Affiliations

Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis

Jacques Brouard et al. J Infect Dis. .

Abstract

Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)-10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position -1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the -1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF.

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