doi: 10.1021/jo0501590.
One-pot Friedel-Crafts/Robinson-Gabriel synthesis of oxazoles using oxazolone templates
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- PMID: 15876123
- DOI: 10.1021/jo0501590
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One-pot Friedel-Crafts/Robinson-Gabriel synthesis of oxazoles using oxazolone templates
J Org Chem.
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Abstract
[reaction: see text] We report herein a one-pot synthesis of 2,4,5-trisubstituted oxazoles via a Friedel-Crafts/Robinson-Gabriel synthesis using a general oxazolone template. Treatment of the oxazolone template with a range of aromatic nucleophiles provided the highly substituted oxazoles in good yields.
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