Review
doi: 10.1016/j.peptides.2005.03.020.
Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors
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- PMID: 15876475
- DOI: 10.1016/j.peptides.2005.03.020
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Review
Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors
Peptides.
2005 Aug.
Abstract
alpha-MSH and gamma-MSH are the natural endogenous hormones for the human melanocortin-1, 3, 4 and 5 receptors (hMC1R, hMC3R, hMC4R and hMC5R). These and more potent, stable and prolonged acting analogues such as NDP-alpha-MSH, MT-II and SHU-9119 are not very receptor selective. To develop potent and selective agonist and antagonist ligands for the melanocortin receptors we have used state-of-the-art biophysical studies, computational chemistry, and design of conformational and topographical constraints with novel templates.
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