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. 2005 Jun;36(6):1207-11.
doi: 10.1161/01.STR.0000165923.02318.22. Epub 2005 May 5.

Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study

Clinton B Wright  1 , Myunghee C Paik, Truman R Brown, Sally P Stabler, Robert H Allen, Ralph L Sacco, Charles DeCarli
Affiliations

Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study

Clinton B Wright et al. Stroke. 2005 Jun.

Abstract

Background: Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations.

Methods: A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency.

Results: Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors.

Conclusions: These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

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References

    1. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1683;43:1683–1689. - PubMed
    1. van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain. 1991;114:761–774. - PubMed
    1. Wong TY, Klein R, Sharrett AR, Couper DJ, Klein BE, Liao DP, Hubbard LD, Mosley TH. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA. 2002;288:67–74. - PubMed
    1. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke. 2003;34:1126–1129. - PubMed
    1. Kuller LH, Shemanski L, Manolio T, Haan M, Fried L, Bryan N, Burke GL, Tracy R, Bhadelia R. Relationship between apoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke. 1998;29:388–398. - PubMed

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