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Review
. 2005 May 7;330(7499):1076-9.
doi: 10.1136/bmj.330.7499.1076.

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

George Davey Smith  1 , Shah Ebrahim
Affiliations
Review

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

George Davey Smith et al. BMJ. .

Abstract

Using genetic variants as a proxy for modifiable environmental factors that are associated with disease can circumvent some of the problems of observational studies

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Figures

Figure 1
Figure 1
Comparison of design of mendelian randomisation studies and randomised controlled trials
Figure 2
Figure 2
Is sheep dip harmful? Turn to Mendelian randomisation Credit: HOLT STUDIOS/NIGEL CATLIN
See this image and copyright information in PMC

References

    1. Le Fanu J. The rise and fall of modern medicine. New York: Little Brown, 1999. - PubMed
    1. Lawlor DA, Davey Smith G, Ebrahim S. The hormone replacement-coronary heart disease conundrum: is this the death of observational epidemiology? Int J Epidemiol 2004;33: 464-7. - PubMed
    1. Lawlor DA, Davey Smith G, Kundu D, Bruckdorfer KR, Ebrahim S. Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence? Lancet 2004;363: 1724-7. - PubMed
    1. Little J, Khoury MJ. Mendelian randomization: a new spin or real progress? Lancet 2003;362: 930-1. - PubMed
    1. Clayton D, McKeigue PM. Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 2001;358: 1356-60. - PubMed

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