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. 2005 May 10;64(9):1621-4.
doi: 10.1212/01.WNL.0000159864.05826.08.

The natural history of Aicardi-Goutières syndrome: follow-up of 11 Italian patients

G Lanzi  1 , E Fazzi, S D'Arrigo, S Orcesi, I Maraucci, C Uggetti, E Bertini, P Lebon
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The natural history of Aicardi-Goutières syndrome: follow-up of 11 Italian patients

G Lanzi et al. Neurology. .

Abstract

Described are the outcomes of 11 Italian patients with Aicardi-Goutières syndrome. Neurologic symptoms progressed in the first year of life and stabilized by the end of the second year in 10 patients. White matter abnormalities remained stable; cerebral atrophy was stable in four patients and progressive in two. Calcifications increased (in number and size) in two of six patients. Serial CSF and serum interferon-alpha measurements (three patients) showed reduced CSF interferon-alpha levels.

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